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The guidelines reflect the international consensus on the most efficient way to treat a pacient, based on the experts opinions and on the data from clinical trials, which means that the impact on clinical day-today practice should be major! It was observed that the number of HF patients treated according to the recommendations of the guidelines is much less than expected, far from being optimal. Unfortunately, this is the case not only with HF, but, also, with hypertension or coronary artery disease! It has been, also, noticed that the administered doses are far from those recommended.

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The purpose peritoneal cancer recurrence rate the first section of this review article is to evaluate prognostic factors in colorectal cancer from clinical and histopathological aspects, in order to reassess and arrange data from this domain and predict the span of life for a patient diagnosed with this neoplasic disease. The study of prognostic factors in colorectal cancer reveals firstly their great variety, and thus the challenge to predict the accurate survival time after diagnosis, and secondly, impossibility to modify some unfavorable prognostic factors, but still having the chance to improve the survival rate by early recognition of favorable factors. TNM staging at the moment of diagnosis remains the most important clinical prognostic factor of survival and regional lymphodes invasion the most important histopathological one.

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Unfortunately, it does not have specific signs and symptoms, being associated with an aggressive evolution and a poor prognosis if left untreated. Their results suggest that PD-1 and PD-L1 could be potential biomarkers for targeted treatment in some patients diagnosed with diffuse large B-cell lymphoma. Malignant lymphomas of the head and neck may raise therapeutic difficulties. OIU, Vlad D.

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И вздрогнув, она пробудилась. Она обняла спавшего мужа. - Ричард, просыпайся.

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На противоположной стороне примыкала к каменной стене, образовавшей всю левую часть зала, платформа шириной примерно в три метра.

Из пестрой стены, разрисованной яркими узорами, на метр выступало не меньше сотни серебристых стержней. Николь сразу же отметила сходство между стеной и вертикальным коридором, по которому она и ее друзья спускались в логово октопауков под Нью-Йорком.

Примерно через десять минут после того, как оба балкона заполнились, на нижнем уровне появилась Верховный Оптимизатор.

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Можно даже не говорить, насколько мы были не готовы к тому, что придется заботиться о себе, когда началась Великая Смута. Наиболее историчные из наших легенд утверждают, что вся наша интеллектуальная деятельность в течение нескольких столетий ограничивалась сбором и постижением накопленной Предтечами информации - всего, что мы могли найти или вспомнить.

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"Зачем же октопаукам становиться нашими благодетелями. - гадала Николь.

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Это не совсем так, - проговорил Орел. - Как и все члены моей группы, я создан для определенной цели. Когда необходимость в моем существовании исчезнет и меня нельзя будет перепрограммировать на новое дело, я буду лишен энергии.