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In the adult organism Bcl-2 expression is generally confined to cells that are rapidly dividing and differentiating. In lymphocytes, Bcl-2 is highly expressed in T-cells, pro-B cells and mature B-cells where lifespan is extended while downregulated in germinal center B-cells where apoptosis forms part of the developmental pathway in order to select only cells producing antibodies with high avidity Overexpression of Bcl-2 is common in many types of cancer, intraductal papilloma ihc non-Hodgkin's lymphoma and leukaemias, adenocarcinomas e. Among the latter, strong Bcl-2 positivity has particularly been demonstrated in gastrointestinal stromal tumor, solitary fibrous tumor, and synovial sarcoma, while fibromatosis and "malignant fibrous histiocytoma" are usually negative.

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Therefore, it is a major challenge of both diagnosis and treatment. We report the case of a year-old woman who was admitted in the Department of Obstetrics and Gynecology of the University Emergency Hospital Bucharest for a palpable tumor located in the supero-lateral quadrant of the right breast.

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Tipologia tumorilor mamare si tratarea lor Din Articole Generalitati Tumorile mamare se clasifica cel mai frecvent in tumori benigne si maligne. Tumorile benigne sunt reprezentate de fibroadenom, hamartom, papilom intraductal si de chisturi mamare simple. Tumorile maligne, cancerul mamar, imbraca diferite forme clinice si histologice. O alta clasificare a tumorilor mamare este in tumori solide si tumori cu continut lichidian chistri mamare.

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