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The publisher's final edited version of this article is available at J Clin Endocrinol Metab See other articles in PMC that cite the published article. Abstract Context The P enzyme aromatase CYP19 plays a crucial role in the endocrine and paracrine biosynthesis of estrogens from androgens in many diverse estrogen-responsive tissues.

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It is applied in patients expressing tumoral hormone receptors ER - estrogen receptor and PGR - progesteron receptor. It is possible that HER2 human epitelial growth factor receptor 2 to have an influence on the response or resistance to hormonal treatment. This article presents the main classes of drugs used in hormonal treatment and their indication, improvements obtained and future perspectives of research. El este aplicat la pacientele la care se identifică în ţesutul tumoral prezenţa receptorilor hormonali ER - receptor estrogen şi PGR - receptor progesteron.

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А темно, чтобы ты не отвлекалась. Наконец они остановились перед высокой дверью. - Зал, в который ты сейчас войдешь, - Орел развернул кресло Николь, - здесь самый крупный: ширина его составляет примерно полкилометра.

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Колонисты в Новом Эдеме не понимают октопауков, - отвечала Николь. - И они не позволяют Арчи и дяде Ричарду объяснить им хоть что-нибудь.

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Такое возможно, - ответил Ричард. - Только помни - необычайные притязания требуют.

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