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Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case. Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule. After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease.

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For over 50 years the casuistic of patients with thyroid cancer registered in the Nuclear Medicine Department of the National Institute of Endocrinology in Bucharest, Romania, has over 12 cases. In the last 6 years, a total of new cases have been added. They are organized in a ‘classic file’ format. As a necessity and the first step in order papillary thyroid cancer nuclear medicine build a digital national database, we developed the BIOMAT-ENDO software as a Windows Forms application that stores all the main data regarding the patient hospitalized in the department, starting with the first hospitalization, continuing with all the periods of radioiodine therapy and the follow up.

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