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Am subliniat pasajele care mi se par semnificative n legtur cu rolul sistemului nervos n patologia cancerului i cu faptul ca mecanismul concret nu era nc cunoscut Cancer survival decreases in patients experiencing various psychosocial stresses 1suggesting a neuroendocrine cancer recurrence role for the central nervous system in progression of malignancy. Specifically, stress- induced changes in neuroendocrine and immune functions may contribute to cancer mortality 2.

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Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers. The ultimate goal is to identify and validate targets for combination therapy with radiation and immunotherapy in preclinical neuroendocrine cancer recurrence, and in parallel conduct studies of biomarkers of response in correlative clinical studies. He has been invited to present his results at over local, national and international meetings, including Grand Rounds, Plenary Talks and Keynote Lectures.

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