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This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving the therapy.

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In the adult organism Bcl-2 expression is generally confined to cells that are rapidly dividing and differentiating. In lymphocytes, Bcl-2 is highly expressed in T-cells, pro-B cells and mature B-cells where lifespan is extended while neuroendocrine cancer ovary in germinal center B-cells where apoptosis forms part of the developmental pathway in order to select only cells producing antibodies with high avidity Overexpression of Bcl-2 is common in many types of cancer, including non-Hodgkin's lymphoma and leukaemias, adenocarcinomas e. Among the latter, strong Bcl-2 positivity has particularly been demonstrated in gastrointestinal stromal tumor, solitary fibrous tumor, and synovial sarcoma, while fibromatosis and "malignant fibrous histiocytoma" are usually negative.

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Criterii de eligibilitate: A. Cancere ale capului şi gâtului tumori ale sferei ORL : a identificarea tumorii primare la pacienţii diagnosticaţi clinic cu adenopatie laterocervicală unică, având examen histopatologic de carcinom scuamos metastatic şi fără detecţie a localizării primare prin alte metode imagistice CT, IRM ; b evaluarea răspunsului la tratament la 3 - 6 luni după radiochimioterapie la pacienţii cu mase tumorale reziduale; c diagnosticul diferenţial al recidivei tumorale suspectate clinic, faţă de efectele locale ale radioterapiei. Cancerele tiroidiene a detecţia bolii reziduale sau a recidivei cancerului tiroidian folicular cu nivele crescute de tireoglobulină şi scintigrama cu radioiod negativă; b evaluarea evoluţiei carcinomului medular tiroidian tratat, asociat cu nivele de calcitonină cu investigaţii imagistice CT, RMN, scintigrafie osoasă sau cu octreotidenormale sau echivoce; c detecţia bolii reziduale sau a recidivei cancerului tiroidian eliminar oxiuros naturalmente cu nivel crescut de tiroglobulină şi scintigramă cu radioiod negativă. Cancerul mamar a evaluarea leziunilor multifocale sau a suspiciunii de recurenţă la pacienţi cu sâni denşi la examen mamografic; b diagnosticul diferenţial al plexopatiei brahiale induse neuroendocrine cancer ovary tratament faţă de invazia tumorală la pacienţi cu examen RMN echivoc sau normal; c evaluarea extensiei bolii la pacienţii cu tumori avansate neuroendocrine cancer ovary d cazuri cu suspiciune de leziuni de recidivă sau metastaze la distanţă în urma unor rezultate crescute ale examenelor de laborator CAfosfataza alcalinăsau suspiciune clinică cu investigaţii imagistice neconcludente sau negative.

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