Life cycle of human papillomavirus

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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.

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PCMC is more frequently found in males and it usually appears between the ages of 50 and Mendoza and Hedwig made the first contemporary description of this eyelid-located tumour.

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