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HPV produces proliferative lesions on the skin and mucous membranes, and the natural evolution of these lesions depends on the type of HPV infections, the way the virus is transmited, the location of the infection, as well as the immune status of the host. In this paper, we described the most common cutaneous manifestations of HPV infection: cutaneous warts and external genital warts. Keywords HPV infection, cutaneous warts, genital warts Rezumat Virusul papiloma uman HPV este un virus ADN care face parte din familia Papaviridae şi pentru care s-au descris mai mult de de tipuri, clasificate în 5 genuri.

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This is one of the most common sexually transmitted infections, with a tropism for tissues such as squamous or mucosal epithelium. Human papillomavirus can be classified according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions.

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Material and method: Sixty patients were included in our study. All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3.

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