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Just wanted to share my personal experience with cervical dysplasia and hpv, and hopefully I can help create awareness about the importance of early detection and regular pap smears. I know that this is still a topic not openly discussed because of the stigma of the disease, but I hope from this thread I can reach out to other women out there with symptoms but are scared to get a thorough check-up.

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The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and hpv causes dysplasia their functions with dysregulation of the cell cycle.

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This is one of the most common sexually transmitted infections, with a tropism for tissues such as squamous or mucosal epithelium. Human papillomavirus can be classified according to the ability of oncogenesis in low-risk genotypes, associated primarily with genital warts and high-risk, associated with premalignant and malignant lesions. The immunization rates for Human papillomavirus are generally lower than for other types of vaccines, and further implementation of appropriate strategies is still needed. Moreover, the way a healthcare provider presents and recommends hpv causes dysplasia vaccine can be decisive in the choice of a person to immunize or not.

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