Colorectal cancer pathways

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Although the causes of this disease are not entirely understood, it is known that several factors influence its occurrence. Risk factors for colorectal cancer include age, family history of colon polyps, inflammatory bowel disease and hereditary syndromes, smoking, obesity, sedentarism, alcohol consumption. Evidence is mounting that detecting this risk factors is a eficient way of selecting persons colorectal cancer pathways high risk for colon cancer, that should undergo the screening mesures. Key words: colon cancer, risk factors, colon polyps, inflammatory bowel disease, smoking, obesity, sedentarism, alcohol consumption.

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Although they seem to lack a clear connection, epidemiologic analysis found a significant association. This led to further evaluation and identification of molecular pathways that stand at the basis of these findings. One of them is chronic inflammation, a state associated with obesity and colorectal cancer.

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Ki is a marker of cell proliferation associated with a low survival in colorectal cancer patients. Its expression is increased in patients with Dukes C or D colorectal cancer versus those in stage A or B.

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