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It is also used to identify colon cancer by checking for hidden or occult blood. Este folosită și pentru identificarea cancerului de colon pentru a verifica sângele ocult sau ascuns. Even if there is an occult blood cancer, you wouldn't expect interferon to make it worse.

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Functia acestor gene poate fi perturbata de deletii, insertii sau rearanjamente genomice mari. O mutatie care inactiveaza gena MMR duce la acumularea de mutatii celulare si creste foarte mult probabilitatea de transformare maligna. Deoarece penetranta mutatiilor este incompleta, aceste anomalii genetice predispun indivizii la cancer, dar nu toti cei care le mostenesc dezvolta tumori. Mutatiile sunt adesea mostenite, dar pot aparea, de asemenea, de novo intr-o generatie.

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